11.21.2011

Mesothelioma and asbestos information needed to know today

The often lethal, rare cancer mesothelioma usually from malignant cells of lung cancer that is widely known as a place approved that includes the result of exposure to asbestos. Asbestos and mesothelioma information you can feel better, this cancer before it's too late. Over the years more than 80 percent of all cases of mesothelioma asbestos were joined in. Those suffering from mesothelioma usually aComplaint of chest pain, turn to a doctor for testing. During these investigations it is common to find that many of the symptoms have been thought of mesothelioma from other diseases. Abdominal pain, breathing difficulties and bottlenecks, and even anemia can be attributed to other causes. Therefore mesothelioma and asbestos information is important in order to create a correct diagnosis.

- Asbestos lung mesothelioma

Where a patient has no symptoms ofMesothelioma can be identified or suspected after physical examination, the cancer spread and to keep getting worse. As the cancer progresses through the stages of untreated, is weight loss, shortness of breath, loss of appetite and night sweats. Here are some facts and diagnosis of mesothelioma.

Mesothelioma and asbestos information needed to know today

The often lethal, rare cancer mesothelioma usually from malignant cells of lung cancer that is widely known as a place approved that includes the result of exposure to asbestos. Asbestos and mesothelioma information you can feel better, this cancer before it's too late. Over the years more than 80 percent of all cases of mesothelioma asbestos were joined in. Those suffering from mesothelioma usually aComplaint of chest pain, turn to a doctor for testing. During these investigations it is common to find that many of the symptoms have been thought of mesothelioma from other diseases. Abdominal pain, breathing difficulties and bottlenecks, and even anemia can be attributed to other causes. Therefore mesothelioma and asbestos information is important in order to create a correct diagnosis.

- Asbestos lung mesothelioma

Where a patient has no symptoms ofMesothelioma can be identified or suspected after physical examination, the cancer spread and to keep getting worse. As the cancer progresses through the stages of untreated, is weight loss, shortness of breath, loss of appetite and night sweats. Here are some facts and diagnosis of mesothelioma.

Information-Your Number Key For Coping With Mesothelioma Cancer

After you receive a diagnosis of mesothelioma you number one priority should be to get adequate information about the disease so that you can make the right informed decisions on the necessary steps you need to take.



When looking for information about mesothelioma cancer, first know what type of mesothelioma you have,the pleural mesothelioma is the commonest but there are also other types of mesothelioma depending on the part of the body that is affected by the cancer. Talk with your health care team. Ask them for information about your specific type of cancer, including the cell type and the stage (extent) of your cancer. This is helpful because your cancer treatment will be designed for just you.



The stage of the cancer, as well as other factors, will help determine the goal of treatment. Most types of mesothelioma cancer treatment have 1 of these 3 goals: provide a cure, control the disease, or ease symptoms of the cancer and help make the patient comfortable. Sometimes the treatment goal changes after treatment has started. Talk with your doctor, and make sure you understand what your treatment options are, so you can make the best decisions for you and your family.



We live in an information-packed age. Cancer information can be complex and confusing. To find accurate and up-to-date information, use reliable sources, such as journals or Web sites from well-respected cancer centers, national cancer organizations, health professional organizations.One good source of information is www.mesotheliomacorner.blogspot.com, you will find the necessary information you need in a very easy to understand manner.



Look for information that has been reviewed by medical experts, is updated often, and states the purpose of the information. When you get information, discuss it with your health care team to find out if and how it applies to you. Remember, written information cannot take the place of medical advice from your doctor or cancer care team.

Information-Your Number Key For Coping With Mesothelioma Cancer

After you receive a diagnosis of mesothelioma you number one priority should be to get adequate information about the disease so that you can make the right informed decisions on the necessary steps you need to take.



When looking for information about mesothelioma cancer, first know what type of mesothelioma you have,the pleural mesothelioma is the commonest but there are also other types of mesothelioma depending on the part of the body that is affected by the cancer. Talk with your health care team. Ask them for information about your specific type of cancer, including the cell type and the stage (extent) of your cancer. This is helpful because your cancer treatment will be designed for just you.



The stage of the cancer, as well as other factors, will help determine the goal of treatment. Most types of mesothelioma cancer treatment have 1 of these 3 goals: provide a cure, control the disease, or ease symptoms of the cancer and help make the patient comfortable. Sometimes the treatment goal changes after treatment has started. Talk with your doctor, and make sure you understand what your treatment options are, so you can make the best decisions for you and your family.



We live in an information-packed age. Cancer information can be complex and confusing. To find accurate and up-to-date information, use reliable sources, such as journals or Web sites from well-respected cancer centers, national cancer organizations, health professional organizations.One good source of information is www.mesotheliomacorner.blogspot.com, you will find the necessary information you need in a very easy to understand manner.



Look for information that has been reviewed by medical experts, is updated often, and states the purpose of the information. When you get information, discuss it with your health care team to find out if and how it applies to you. Remember, written information cannot take the place of medical advice from your doctor or cancer care team.

Virginia Employees At-Risk For Asbestos Diseases Should Seek Periodic Medical Exams

Workers who have a history of asbestos exposure in Virginia should be checked often for asbestos-related illnesses. Those who worked in the armed forces, refineries, auto factories, shipyards and chemical plants in Virginia??before the 1980s should tell their doctors about their potential exposure to asbestos. Early detection is important in many cases of asbestos-related diseases, as even lung cancers have a better prognosis when caught early.

Caused by the inhalation of asbestos fibers, asbestosis is a scarring of the lower lobes of the lungs. Virginia workers who were employed in certain industries, such as shipbuilding, automotive repairs and mining, should be on alert for asbestosis and other asbestos-related diseases. At-risk workers in Virginia who have a history of asbestos exposure should see their physicians for periodic asbestosis screenings. To detect asbestosis, the physician will take an x-ray of the lungs, which will be evaluated by a certified radiologist. This diagnostic tool can establish whether the patient has scarred lung tissue, which is often associated with asbestos exposure. Although asbestosis is not typically deadly, it can become progressive and may require the patient to depend on inhalers. Patients who have been diagnosed with asbestosis should undergo regular x-rays and lung function tests to track the development of the disease.

Shipyards Asbestos Exposure and the Mesothelioma Menace

Asbestos is a naturally occurring mineral that was widely used in a variety of products.?? Asbestos only becomes dangerous when it is broken into small pieces that become airborne.?? When these small pieces of asbestos dust are inhaled they settle into the lungs and can cause life threatening diseases.?? One interesting study is called, "Screening for asbestos-induced diseases in Finland" by Kari Koskinen, MD, Jouko-Pekka Rinne, MD, Anders Zitting, MD, Antti Tossavainen, DTech, Jukka Kivek??s, MD, Kari Reijula, MD, Pekka Roto, MD, MIH, Matti S. Huuskonen, MD, MSc - Finnish Institute of Occupational Health, Helsinki, Finland - American Journal of Industrial Medicine - Volume 30 Issue 3, Pages 241 – 251.?? Here is an excerpt: "Abstract - Screening for asbestos-induced diseases in Finland was carried out in 1990-1992 as a part of the Asbestos Program of the Finnish Institute of Occupational Health. The aim of the present study was to find the workers who had developed an asbestos-induced disease in certain occupations. Examination of active or retired workers included a personal interview on work history and asbestos exposure, and a chest X-ray. The target group for the screening comprised workers under 70 years of age who had worked at least for 10 years in construction, 1 year in a shipyard or in the manufacture of asbestos products. A preliminary questionnaire was sent to 54,409 workers, 18,943 of whom finally participated in the screening examination. The mean age of the workers was 53 years; 95% were employed in construction, 2% in shipyards, and 3% in the asbestos industry. The criteria for a positive screening result were (1) a radiographic finding clearly indicating lung fibrosis (at least ILO category 1/1), (2) a radiographic finding indicating mild lung fibrosis (ILO category I/O) with unilateral or bilateral pleural plaques, (3) marked abnormalities of the visceral pleura (marked adhesions with or without pleural thickening), or (4) bilateral pleural plaques. The positive cases totalled 4,133 (22%) and were sent for further investigation. In addition to the screening, information on the presence of asbestos in the work environment, prevention of asbestos exposure, as well as on the health effects of asbestos exposure and smoking were given to the participating workers. The screening acted as a preliminary survey to prompt further national follow-up of asbestos-induced diseases among the workers who have been exposed to asbestos. This article presents the material, methods, and overall results of the screening. ??

A second study is called, "Clara cell protein (CC-16) and surfactant-associated protein A (SP-A) in asbestos-exposed workers." By Lesur O, Bernard AM, Bégin RO - Unité de Recherche Pulmonaire, Université de Sherbrooke, Québec, Canada.?? Chest. 1996 Feb;109(2):467-74.?? Here is an excerpt: "Abstract - Asbestos-exposed workers (Asb) can sometimes develop lung impairments resembling idiopathic pulmonary fibrosis (IPF). Smoking is often a troubling confounder in the natural history of these lung diseases. Distal airspace epithelial cells, which are also altered in asbestosis, secrete Clara cell protein (CC-16, also designated CC-10) and surfactant-associated protein A (SP-A). By inhibiting phospholipase A2 (PLA2), CC-16 and SP-A are putative candidates for controlling lung inflammatory events. Both were measured with PLA2 activity in alveolar fluids (and sera for CC-16) of smoker and nonsmoker Asb and compared with smoking-matched normal subjects (N). CC-16 (in mg/L) was slightly increased in Asb and affected by smoking: nonsmoker Asb: 3.1 +/- 0.5 vs nonsmoker N: 1.9 +/- 0.2 (p < 0.05), smoker Asb: 1.7 +/- 0.3 vs smoker N: 0.6 +/- 0.1 (p < 0.05). SP-A (in microgram/mL) was enhanced in Asb but not affected by smoking: 5.4 +/- 1.5 in Asb vs 1.6 +/- 0.4 in N (p < 0.05), whereas SP-A to phosphorus ratio was increased in Asb but affected by smoking. CC-16 to albumin and CC-16 in serum to alveolar fluid ratios were altered by cigarette consumption in Asb (p < 0.05 vs N). Secretory PLA2 activity was slightly enhanced in Asb (p < 0.05 vs N). All data were similar between stages of disease. In summary, alveolar CC-16, SP-A, and secretory PLA2 activity were increased in Asb. Smoking affected several parameters. By this habit, Asb might reinforce lung profibrotic factors and increase their risk in developing lung alterations resembling IPF."

If you found any of these studies interesting, please read them in their entirety.?? We all owe a great deal of thanks to the people who are researching these important issues.

Shipyards Asbestos Exposure and the Mesothelioma Menace

Asbestos is a naturally occurring mineral that was widely used in a variety of products.?? Asbestos only becomes dangerous when it is broken into small pieces that become airborne.?? When these small pieces of asbestos dust are inhaled they settle into the lungs and can cause life threatening diseases.?? One interesting study is called, "Screening for asbestos-induced diseases in Finland" by Kari Koskinen, MD, Jouko-Pekka Rinne, MD, Anders Zitting, MD, Antti Tossavainen, DTech, Jukka Kivek??s, MD, Kari Reijula, MD, Pekka Roto, MD, MIH, Matti S. Huuskonen, MD, MSc - Finnish Institute of Occupational Health, Helsinki, Finland - American Journal of Industrial Medicine - Volume 30 Issue 3, Pages 241 – 251.?? Here is an excerpt: "Abstract - Screening for asbestos-induced diseases in Finland was carried out in 1990-1992 as a part of the Asbestos Program of the Finnish Institute of Occupational Health. The aim of the present study was to find the workers who had developed an asbestos-induced disease in certain occupations. Examination of active or retired workers included a personal interview on work history and asbestos exposure, and a chest X-ray. The target group for the screening comprised workers under 70 years of age who had worked at least for 10 years in construction, 1 year in a shipyard or in the manufacture of asbestos products. A preliminary questionnaire was sent to 54,409 workers, 18,943 of whom finally participated in the screening examination. The mean age of the workers was 53 years; 95% were employed in construction, 2% in shipyards, and 3% in the asbestos industry. The criteria for a positive screening result were (1) a radiographic finding clearly indicating lung fibrosis (at least ILO category 1/1), (2) a radiographic finding indicating mild lung fibrosis (ILO category I/O) with unilateral or bilateral pleural plaques, (3) marked abnormalities of the visceral pleura (marked adhesions with or without pleural thickening), or (4) bilateral pleural plaques. The positive cases totalled 4,133 (22%) and were sent for further investigation. In addition to the screening, information on the presence of asbestos in the work environment, prevention of asbestos exposure, as well as on the health effects of asbestos exposure and smoking were given to the participating workers. The screening acted as a preliminary survey to prompt further national follow-up of asbestos-induced diseases among the workers who have been exposed to asbestos. This article presents the material, methods, and overall results of the screening. ??

A second study is called, "Clara cell protein (CC-16) and surfactant-associated protein A (SP-A) in asbestos-exposed workers." By Lesur O, Bernard AM, Bégin RO - Unité de Recherche Pulmonaire, Université de Sherbrooke, Québec, Canada.?? Chest. 1996 Feb;109(2):467-74.?? Here is an excerpt: "Abstract - Asbestos-exposed workers (Asb) can sometimes develop lung impairments resembling idiopathic pulmonary fibrosis (IPF). Smoking is often a troubling confounder in the natural history of these lung diseases. Distal airspace epithelial cells, which are also altered in asbestosis, secrete Clara cell protein (CC-16, also designated CC-10) and surfactant-associated protein A (SP-A). By inhibiting phospholipase A2 (PLA2), CC-16 and SP-A are putative candidates for controlling lung inflammatory events. Both were measured with PLA2 activity in alveolar fluids (and sera for CC-16) of smoker and nonsmoker Asb and compared with smoking-matched normal subjects (N). CC-16 (in mg/L) was slightly increased in Asb and affected by smoking: nonsmoker Asb: 3.1 +/- 0.5 vs nonsmoker N: 1.9 +/- 0.2 (p < 0.05), smoker Asb: 1.7 +/- 0.3 vs smoker N: 0.6 +/- 0.1 (p < 0.05). SP-A (in microgram/mL) was enhanced in Asb but not affected by smoking: 5.4 +/- 1.5 in Asb vs 1.6 +/- 0.4 in N (p < 0.05), whereas SP-A to phosphorus ratio was increased in Asb but affected by smoking. CC-16 to albumin and CC-16 in serum to alveolar fluid ratios were altered by cigarette consumption in Asb (p < 0.05 vs N). Secretory PLA2 activity was slightly enhanced in Asb (p < 0.05 vs N). All data were similar between stages of disease. In summary, alveolar CC-16, SP-A, and secretory PLA2 activity were increased in Asb. Smoking affected several parameters. By this habit, Asb might reinforce lung profibrotic factors and increase their risk in developing lung alterations resembling IPF."

If you found any of these studies interesting, please read them in their entirety.?? We all owe a great deal of thanks to the people who are researching these important issues.

Mesothelioma Cell Lines Using Indirect Immunofluorescence and Northern Blotting

One interesting study is called, "HLA antigen expression and malignant mesothelioma." By Christmas TI, Manning LS, Davis MR, Robinson BW, Garlepp MJ. - Department of Medicine, University of Western Australia, Queen Elizabeth II Medical Centre, Nedlands.?? Am J Respir Cell Mol Biol. 1991 Sep;5(3):213-20.?? Here is an excerpt: "Abstract - The expression of HLA antigens by a tumor may determine its progression and metastatic potential by influencing the immune response to that tumor. The upregulation of HLA antigen expression on some cell types by interferons (IFNs) may contribute to their antitumor activity. Malignant mesothelioma (MM) is a tumor that has a poor prognosis and is unaffected by conventional therapy, although immunotherapy has not been adequately assessed. In this study, we have examined the constitutive and IFN-inducible expression of class I and class II HLA antigens on MM cell lines using indirect immunofluorescence and Northern blotting. All MM cell lines constitutively expressed class I, but not class II, surface antigen, and all three class I loci (HLA-A, HLA-B, and HLA-C) were expressed. The MM cell lines were heterogeneous in their response to the IFNs. Treatment with IFN-alpha marginally increased class I surface expression, but not class II. Class I mRNA was, however, clearly increased in all cell lines after IFN-alpha treatment, suggesting that class I surface antigen was already maximally expressed. IFN-gamma increased class I mRNA expression in all but one cell line and induced DR expression on three of the cell lines. DQ-beta, but not DQ-alpha, mRNA was inducible in the same three cell lines, but DQ surface antigen was never demonstrable."

Another interesting study is called, "Malignant pleural mesothelioma: a problematic review" by Thomas L. Moskal, John D. Urschel, Timothy M. Anderson, Joseph G. Antkowiak, Hiroshi Takita - Volume 7, Issue 1, Pages 5-12 (July 1998).?? Here is an excerpt: "Abstract - Malignant pleural mesothelioma is a rare tumor that has been difficult to study. Because of disappointing treatment results, malignant pleural mesothelioma has remained an area of active research and development. A clinicopathologic review is performed in light of several problematic issues involving diagnosis, staging, natural history, and treatment. Multimodality treatment with surgery followed by adjuvant local and systemic therapy remains the most optimal therapy. Many controversial issues still exist in the treatment of malignant pleural mesothelioma. In the ensuing years newer staging systems, better preoperative staging, newer experimental therapies, and the localization of patients at expert centers will undoubtedly have an impact on disease management."

Mesothelioma Cell Lines Using Indirect Immunofluorescence and Northern Blotting

One interesting study is called, "HLA antigen expression and malignant mesothelioma." By Christmas TI, Manning LS, Davis MR, Robinson BW, Garlepp MJ. - Department of Medicine, University of Western Australia, Queen Elizabeth II Medical Centre, Nedlands.?? Am J Respir Cell Mol Biol. 1991 Sep;5(3):213-20.?? Here is an excerpt: "Abstract - The expression of HLA antigens by a tumor may determine its progression and metastatic potential by influencing the immune response to that tumor. The upregulation of HLA antigen expression on some cell types by interferons (IFNs) may contribute to their antitumor activity. Malignant mesothelioma (MM) is a tumor that has a poor prognosis and is unaffected by conventional therapy, although immunotherapy has not been adequately assessed. In this study, we have examined the constitutive and IFN-inducible expression of class I and class II HLA antigens on MM cell lines using indirect immunofluorescence and Northern blotting. All MM cell lines constitutively expressed class I, but not class II, surface antigen, and all three class I loci (HLA-A, HLA-B, and HLA-C) were expressed. The MM cell lines were heterogeneous in their response to the IFNs. Treatment with IFN-alpha marginally increased class I surface expression, but not class II. Class I mRNA was, however, clearly increased in all cell lines after IFN-alpha treatment, suggesting that class I surface antigen was already maximally expressed. IFN-gamma increased class I mRNA expression in all but one cell line and induced DR expression on three of the cell lines. DQ-beta, but not DQ-alpha, mRNA was inducible in the same three cell lines, but DQ surface antigen was never demonstrable."

Another interesting study is called, "Malignant pleural mesothelioma: a problematic review" by Thomas L. Moskal, John D. Urschel, Timothy M. Anderson, Joseph G. Antkowiak, Hiroshi Takita - Volume 7, Issue 1, Pages 5-12 (July 1998).?? Here is an excerpt: "Abstract - Malignant pleural mesothelioma is a rare tumor that has been difficult to study. Because of disappointing treatment results, malignant pleural mesothelioma has remained an area of active research and development. A clinicopathologic review is performed in light of several problematic issues involving diagnosis, staging, natural history, and treatment. Multimodality treatment with surgery followed by adjuvant local and systemic therapy remains the most optimal therapy. Many controversial issues still exist in the treatment of malignant pleural mesothelioma. In the ensuing years newer staging systems, better preoperative staging, newer experimental therapies, and the localization of patients at expert centers will undoubtedly have an impact on disease management."

Information on Mesothelioma

In case you are someone who likes to fully understand in detail regarding information on mesothelioma cancer, in that case you currently have stumbled on the appropriate site. This write-up will teach you all that you needed to know about this scary type of cancer.

Mesothelioma is a distinct kind of cancer that is triggered by precariously large levels of exposure to asbestos. Medical study has proven the direct connection among this often dangerous kind of cancer and asbestos. Mesothelioma cancer typically begins around the coating of the lung tissue, before it distributes its tentacles to various other areas of the body.

Generally there has been an increase in the quantities of attention about this specific type of cancer all over the world. This has lead to protests towards the use of asbestos in numerous countries. In fact, the increasing awareness levels have intended that asbestos is now prohibited in several areas. Industrial facilities and commercial institutions are right now varying of utilizing asbestos for this cause.

Information on Mesothelioma

In case you are someone who likes to fully understand in detail regarding information on mesothelioma cancer, in that case you currently have stumbled on the appropriate site. This write-up will teach you all that you needed to know about this scary type of cancer.

Mesothelioma is a distinct kind of cancer that is triggered by precariously large levels of exposure to asbestos. Medical study has proven the direct connection among this often dangerous kind of cancer and asbestos. Mesothelioma cancer typically begins around the coating of the lung tissue, before it distributes its tentacles to various other areas of the body.

Generally there has been an increase in the quantities of attention about this specific type of cancer all over the world. This has lead to protests towards the use of asbestos in numerous countries. In fact, the increasing awareness levels have intended that asbestos is now prohibited in several areas. Industrial facilities and commercial institutions are right now varying of utilizing asbestos for this cause.

Vitamin C Consumption May Disrupt Mesothelioma Cancer Therapy

Copyright (c) 2008 Katie Kelley



According to research published in the medical journal Cancer Research, approximately 30 to 70 percent fewer cancerous cells were being adequately treated during chemotherapy treatments when a patient consumed vitamin C.



Patients who have developed mesothelioma cancer and who are undergoing chemotherapy should avoid consuming vitamin C, according to the study.



Chemotherapy and Mesothelioma Cancer



Chemotherapy is a form of treatment for cancer and can be administered in a number of ways, via a pill or through an needle injection. Chemotherapy can is also administered either intrapleurally, which is directly into the chest cavity, or intraperitoneally, which is an injection of chemotherapy drugs directly into the abdominal cavity, according to the American Cancer Society (ACS).



Unfortunately, chemotherapy is one of the only treatments for signs and symptoms of the disease, although it can be given at any stage of the cancer. According to the ACS, the following are drugs used in combination during chemotherapy:

Vitamin C Consumption May Disrupt Mesothelioma Cancer Therapy

Copyright (c) 2008 Katie Kelley



According to research published in the medical journal Cancer Research, approximately 30 to 70 percent fewer cancerous cells were being adequately treated during chemotherapy treatments when a patient consumed vitamin C.



Patients who have developed mesothelioma cancer and who are undergoing chemotherapy should avoid consuming vitamin C, according to the study.



Chemotherapy and Mesothelioma Cancer



Chemotherapy is a form of treatment for cancer and can be administered in a number of ways, via a pill or through an needle injection. Chemotherapy can is also administered either intrapleurally, which is directly into the chest cavity, or intraperitoneally, which is an injection of chemotherapy drugs directly into the abdominal cavity, according to the American Cancer Society (ACS).



Unfortunately, chemotherapy is one of the only treatments for signs and symptoms of the disease, although it can be given at any stage of the cancer. According to the ACS, the following are drugs used in combination during chemotherapy:

New Mesothelioma Test - Showing Effectiveness for Pleural Mesothelioma Patients

Mesothelioma is an asbestos related cancer caused by exposure to asbestos over a long period of time. Symptoms for mesothelioma may not become apparent for decades after the initial exposure to asbestos. Thus it is usually not detected until the late stages after serious side effects begin to present themselves.

What Are Some Of The Diagnosis Of Pleural Mesothelioma?

Mesothelioma in general is extremely difficult to diagnose since symptoms do not appear for a long time after initial asbestos exposure occurs. And in most cases pleural mesothelioma is often mistaken for influenza or pneumonia or other more common disease making it extremely difficult to diagnose and treat.

What Are The Symptoms Of Pleural Mesothelioma?

The symptoms of pleural mesothelioma are very non-specific which makes it very difficult to diagnose at an early stage and treat appropriately. Other symptoms may not appear for decades after exposure to asbestos. Some of the symptoms include:

  • Abdominal swelling
  • Anemia
  • Acute pain in the abdominal region and chest area
  • Coughing up blood
  • Difficulty swallowing
  • Fatigue
  • Shortness of breath
  • Persistent dry cough
  • Weight loss

What Is This New Test?

A new gene ratio test to help predict which pleural mesothelioma patients will benefit from multiple modes of therapy and surgical procedure was developed by researchers at the Birgham and Womens Hospital in Boston, Massachusetts. This test has shown to be effective in predicting postsurgical outcome in pleural mesothelioma patient – this is indeed a very important breakthrough in the diagnosis and treatment of mesothelioma.

How Is This Test Used?

New Mesothelioma Test - Showing Effectiveness for Pleural Mesothelioma Patients

Mesothelioma is an asbestos related cancer caused by exposure to asbestos over a long period of time. Symptoms for mesothelioma may not become apparent for decades after the initial exposure to asbestos. Thus it is usually not detected until the late stages after serious side effects begin to present themselves.

What Are Some Of The Diagnosis Of Pleural Mesothelioma?

Mesothelioma in general is extremely difficult to diagnose since symptoms do not appear for a long time after initial asbestos exposure occurs. And in most cases pleural mesothelioma is often mistaken for influenza or pneumonia or other more common disease making it extremely difficult to diagnose and treat.

What Are The Symptoms Of Pleural Mesothelioma?

The symptoms of pleural mesothelioma are very non-specific which makes it very difficult to diagnose at an early stage and treat appropriately. Other symptoms may not appear for decades after exposure to asbestos. Some of the symptoms include:

  • Abdominal swelling
  • Anemia
  • Acute pain in the abdominal region and chest area
  • Coughing up blood
  • Difficulty swallowing
  • Fatigue
  • Shortness of breath
  • Persistent dry cough
  • Weight loss

What Is This New Test?

A new gene ratio test to help predict which pleural mesothelioma patients will benefit from multiple modes of therapy and surgical procedure was developed by researchers at the Birgham and Womens Hospital in Boston, Massachusetts. This test has shown to be effective in predicting postsurgical outcome in pleural mesothelioma patient – this is indeed a very important breakthrough in the diagnosis and treatment of mesothelioma.

How Is This Test Used?

Dealing with Mesothelioma in the Family

When a family member has Mesothelioma, it can be incredibly difficult on all members of the family. Often the victim goes from being relatively healthy to being in critical condition very rapidly. It is very important to understand as much about how to deal with this disease as a family as it is to understand the disease itself.

The Disease

Mesothelioma is a form of asbestos cancer which affects the lining of the lungs, stomach or heart. The common symptoms for the disease are breathlessness, pain in the chest and in the rib cage. If your family member has been diagnosed with Mesothelioma, based on the stage, they need to have some form of mesothelioma treatment and understand that there is no cure. When considering treatment, they need to consider various aspects like:

  • Benefits of the treatment
  • Insurance coverage
  • Payment modalities
  • Logistics
  • Side effects of the treatment

The Role of the Family

When a family member is diagnosed with Mesothelioma, it results in a great amount of stress to all the family members as each member wants to get answers for all their questions related to the disease, its effects and the future of the family. It is advised that families seek the help of support groups who help in dealing with the stress as well as the effects of the disease. Along with the patient, the family members also feel helpless and face emotions of anger, sorrow as well as confusion.

Dealing with Mesothelioma in the Family

When a family member has Mesothelioma, it can be incredibly difficult on all members of the family. Often the victim goes from being relatively healthy to being in critical condition very rapidly. It is very important to understand as much about how to deal with this disease as a family as it is to understand the disease itself.

The Disease

Mesothelioma is a form of asbestos cancer which affects the lining of the lungs, stomach or heart. The common symptoms for the disease are breathlessness, pain in the chest and in the rib cage. If your family member has been diagnosed with Mesothelioma, based on the stage, they need to have some form of mesothelioma treatment and understand that there is no cure. When considering treatment, they need to consider various aspects like:

  • Benefits of the treatment
  • Insurance coverage
  • Payment modalities
  • Logistics
  • Side effects of the treatment

The Role of the Family

When a family member is diagnosed with Mesothelioma, it results in a great amount of stress to all the family members as each member wants to get answers for all their questions related to the disease, its effects and the future of the family. It is advised that families seek the help of support groups who help in dealing with the stress as well as the effects of the disease. Along with the patient, the family members also feel helpless and face emotions of anger, sorrow as well as confusion.

Dealing with Mesothelioma in the Family

When a family member has Mesothelioma, it can be incredibly difficult on all members of the family. Often the victim goes from being relatively healthy to being in critical condition very rapidly. It is very important to understand as much about how to deal with this disease as a family as it is to understand the disease itself.

The Disease

Mesothelioma is a form of asbestos cancer which affects the lining of the lungs, stomach or heart. The common symptoms for the disease are breathlessness, pain in the chest and in the rib cage. If your family member has been diagnosed with Mesothelioma, based on the stage, they need to have some form of mesothelioma treatment and understand that there is no cure. When considering treatment, they need to consider various aspects like:

  • Benefits of the treatment
  • Insurance coverage
  • Payment modalities
  • Logistics
  • Side effects of the treatment

The Role of the Family

When a family member is diagnosed with Mesothelioma, it results in a great amount of stress to all the family members as each member wants to get answers for all their questions related to the disease, its effects and the future of the family. It is advised that families seek the help of support groups who help in dealing with the stress as well as the effects of the disease. Along with the patient, the family members also feel helpless and face emotions of anger, sorrow as well as confusion.

11.20.2011

Mesothellioma Information

WHAT IS MESOTHELIOMA


Mesothelioma may be a rare sort of cancer (malignancy) that the majority arises from the cells lining the sacs of the chest (the pleura) or the abdomen (the peritoneum). Pleural mesothelioma is that the most typical type, usually presenting with symptoms within the chest space. Peritoneal mesothelioma is way less common. this could result the organs within the abdomen, and its symptoms are associated with this space of the body, that is, abdominal swelling, nausea, vomiting, and bowel obstruction. The rarest sort of mesothelioma is pericardial mesothelioma, that involves the sac surrounding the guts.There are two major cell kinds of mesothelioma, epithelial and sarcomatoid.

WHAT ARE THE CAUSES OF MESOTHELIOMA
Exposure to asbestos is that the leading reason for mesothelioma cancer. Exposure will occur by either inhaling or ingesting asbestos fibers, which usually become airborne when asbestos-containing merchandise are broken. When these microscopic fibers are inhaled, they'll become lodged within the lining of the lungs and cause pleural mesothelioma. When ingested, the fibers will become lodged within the lining of the abdomen and result in peritoneal mesothelioma.

Mesothellioma Information

WHAT IS MESOTHELIOMA


Mesothelioma may be a rare sort of cancer (malignancy) that the majority arises from the cells lining the sacs of the chest (the pleura) or the abdomen (the peritoneum). Pleural mesothelioma is that the most typical type, usually presenting with symptoms within the chest space. Peritoneal mesothelioma is way less common. this could result the organs within the abdomen, and its symptoms are associated with this space of the body, that is, abdominal swelling, nausea, vomiting, and bowel obstruction. The rarest sort of mesothelioma is pericardial mesothelioma, that involves the sac surrounding the guts.There are two major cell kinds of mesothelioma, epithelial and sarcomatoid.

WHAT ARE THE CAUSES OF MESOTHELIOMA
Exposure to asbestos is that the leading reason for mesothelioma cancer. Exposure will occur by either inhaling or ingesting asbestos fibers, which usually become airborne when asbestos-containing merchandise are broken. When these microscopic fibers are inhaled, they'll become lodged within the lining of the lungs and cause pleural mesothelioma. When ingested, the fibers will become lodged within the lining of the abdomen and result in peritoneal mesothelioma.

Mesothelioma Therapy with the Antiestrogen Tamoxifen

Another interesting study is called, "The Antiestrogen Tamoxifen in the Treatment of Recurrent Benign Cystic Mesothelioma" by Gerard S. Letteriea, and Joseph L. Yonb -
Gynecologic Oncology Volume 70, Issue 1, July 1998, Pages 131-133.?? Here is an excerpt:?? "Abstract - Benign cystic mesothelioma is a tumor characteristically found in women during the reproductive years. These tumors are infrequently found after castration or menopause, suggesting some degree of hormonal sensitivity. Such aspects of the tumor suggest a potential role for antiestrogens as medical management and an alternative to radical surgery. We treated a 19-year-old woman with a symptomatic pelvic mass secondary to a recurrent benign cystic mesothelioma 2 years after radical surgery with the antiestrogen tamoxifen. An initial reduction in volume and arrest of growth was followed by stabilization in size and disappearance of symptoms. Therapy was continued for 18 months with no change in the volume of the cystic structure. The patient continued to be asymptomatic. Periodic surveillance with quantitative digital radiography for bone density showed no change in bone mineral density. Serum testing for liver function studies was normal throughout treatment. This case suggests that antiestrogens may have a role in the medical management of these rare estrogen-dependent neoplasms. The initial reduction in size and arrest in growth further suggest extreme sensitivity of this tumor to manipulation of the hormonal milieu. Therapy with the antiestrogen tamoxifen in this setting may provide an option for long-term medical management in cases of symptomatic recurrent cystic mesotheliomas."

Another interesting study is called, "Expression profile of telomerase subunits in human pleural Mesothelioma" by Karl Dhaene, Jan Wauters, Barbara Weyn, Jean-Pierre Timmermans, Eric van Marck - The Journal of Pathology Volume 190, Issue 1, pages 80–85, January 2000.?? Here is an excerpt: "Abstract - Using the TRAP assay, telomerase activity was previously detected in over 90% of human pleural mesotheliomas (MMs), but not in mesothelial cell cultures (MCCs), suggesting that telomerase re-activation occurs during multi-step mesothelioma carcinogenesis. The present study determined the expression of the telomerase RNA template (hTERC), the telomerase-associated protein (hTEP1), and the telomerase catalytic sub-unit (hTERT), in 16 pleural MMs and 4 MM-derived cell lines, in two pleural solitary fibrous tumours and in six MCCs. Reverse transcription-polymerase chain reaction analysis revealed that hTERT mRNA expression parallels the activity status documented by the TRAP assay, whereas hTERC and hTEP1 mRNA are commonly expressed in all malignant and non-malignant serosal cells and tissues. Three alternatively spliced hTERT transcripts were detected in all telomerase-positive samples, whereas neither variant could be detected in the MCCs. Detection of the hTERT protein with a commercially available antibody was not successful. These results indicate that hTERT expression is rate-limiting for human telomerase activity and that re-activation, rather than up-regulation, of hTERT expression can play a critical role in MM carcinogenesis. While waiting suitable anti-hTERT antibodies, these results provide information for the design of hTERT mRNA-specific in situ probes to study telomerase in archived pre-malignant serosal lesions."

We all owe a debt of gratitude to these fine researchers.?? If you found any of these excerpts interesting, please read the studies in their entirety.

Mesothelioma Therapy with the Antiestrogen Tamoxifen

Another interesting study is called, "The Antiestrogen Tamoxifen in the Treatment of Recurrent Benign Cystic Mesothelioma" by Gerard S. Letteriea, and Joseph L. Yonb -
Gynecologic Oncology Volume 70, Issue 1, July 1998, Pages 131-133.?? Here is an excerpt:?? "Abstract - Benign cystic mesothelioma is a tumor characteristically found in women during the reproductive years. These tumors are infrequently found after castration or menopause, suggesting some degree of hormonal sensitivity. Such aspects of the tumor suggest a potential role for antiestrogens as medical management and an alternative to radical surgery. We treated a 19-year-old woman with a symptomatic pelvic mass secondary to a recurrent benign cystic mesothelioma 2 years after radical surgery with the antiestrogen tamoxifen. An initial reduction in volume and arrest of growth was followed by stabilization in size and disappearance of symptoms. Therapy was continued for 18 months with no change in the volume of the cystic structure. The patient continued to be asymptomatic. Periodic surveillance with quantitative digital radiography for bone density showed no change in bone mineral density. Serum testing for liver function studies was normal throughout treatment. This case suggests that antiestrogens may have a role in the medical management of these rare estrogen-dependent neoplasms. The initial reduction in size and arrest in growth further suggest extreme sensitivity of this tumor to manipulation of the hormonal milieu. Therapy with the antiestrogen tamoxifen in this setting may provide an option for long-term medical management in cases of symptomatic recurrent cystic mesotheliomas."

Another interesting study is called, "Expression profile of telomerase subunits in human pleural Mesothelioma" by Karl Dhaene, Jan Wauters, Barbara Weyn, Jean-Pierre Timmermans, Eric van Marck - The Journal of Pathology Volume 190, Issue 1, pages 80–85, January 2000.?? Here is an excerpt: "Abstract - Using the TRAP assay, telomerase activity was previously detected in over 90% of human pleural mesotheliomas (MMs), but not in mesothelial cell cultures (MCCs), suggesting that telomerase re-activation occurs during multi-step mesothelioma carcinogenesis. The present study determined the expression of the telomerase RNA template (hTERC), the telomerase-associated protein (hTEP1), and the telomerase catalytic sub-unit (hTERT), in 16 pleural MMs and 4 MM-derived cell lines, in two pleural solitary fibrous tumours and in six MCCs. Reverse transcription-polymerase chain reaction analysis revealed that hTERT mRNA expression parallels the activity status documented by the TRAP assay, whereas hTERC and hTEP1 mRNA are commonly expressed in all malignant and non-malignant serosal cells and tissues. Three alternatively spliced hTERT transcripts were detected in all telomerase-positive samples, whereas neither variant could be detected in the MCCs. Detection of the hTERT protein with a commercially available antibody was not successful. These results indicate that hTERT expression is rate-limiting for human telomerase activity and that re-activation, rather than up-regulation, of hTERT expression can play a critical role in MM carcinogenesis. While waiting suitable anti-hTERT antibodies, these results provide information for the design of hTERT mRNA-specific in situ probes to study telomerase in archived pre-malignant serosal lesions."

We all owe a debt of gratitude to these fine researchers.?? If you found any of these excerpts interesting, please read the studies in their entirety.

Denver Mesothelioma Attorneys

What is Mesothelioma?

The National Cancer Institute states that, “Malignant mesothelioma, a rare form of cancer, is a disease in which malignant cells are found in the lining of the chest or abdomen.”

How do you get Mesothelioma?

Most people who develop mesothelioma have worked on jobs where they inhale asbestos particles or have been exposed to asbestos dust and fiber in other ways like on the skin.

What are some of the Signs and Symptoms of Mesothelioma?

The symptoms of mesothelioma may not appear until 20 to 50 years after exposure to asbestos. Some of the signs and symptoms include: weight loss, shortness of breath, fatigue, acute pain in the abdominal region and chest area, abdominal swelling and anemia.

What are some of the Treatments used for Mesothelioma?

Treatments include: conventional therapies, surgeries, chemotherapy, radiation therapy, immunotherapy, and or a combination of treatment and medications.

Are there Legal Issues involved in Mesothelioma?

If you or someone you love has been diagnosed with mesothelioma, you may have legal right to seek compensation from the companies responsible for your exposure to asbestos. If you wish to seek compensation for your diagnosis and the pain and suffering that comes with mesothelioma, then it is important that you consult an attorney immediately.

What should I do after being diagnosed with Mesothelioma in Denver?

Denver Mesothelioma Attorneys

What is Mesothelioma?

The National Cancer Institute states that, “Malignant mesothelioma, a rare form of cancer, is a disease in which malignant cells are found in the lining of the chest or abdomen.”

How do you get Mesothelioma?

Most people who develop mesothelioma have worked on jobs where they inhale asbestos particles or have been exposed to asbestos dust and fiber in other ways like on the skin.

What are some of the Signs and Symptoms of Mesothelioma?

The symptoms of mesothelioma may not appear until 20 to 50 years after exposure to asbestos. Some of the signs and symptoms include: weight loss, shortness of breath, fatigue, acute pain in the abdominal region and chest area, abdominal swelling and anemia.

What are some of the Treatments used for Mesothelioma?

Treatments include: conventional therapies, surgeries, chemotherapy, radiation therapy, immunotherapy, and or a combination of treatment and medications.

Are there Legal Issues involved in Mesothelioma?

If you or someone you love has been diagnosed with mesothelioma, you may have legal right to seek compensation from the companies responsible for your exposure to asbestos. If you wish to seek compensation for your diagnosis and the pain and suffering that comes with mesothelioma, then it is important that you consult an attorney immediately.

What should I do after being diagnosed with Mesothelioma in Denver?

Find out how you can locate the very best asbestos attorneys

When you have already been clinically determined to have mesotholioma due to asbestos fiber coverage, after that ask legal aid from mesotholioma lawyers straight away. These kind of attorneys might be there in your case in the filling of your respective situation until finally you may end up being rewarded effectively. The legal course of action for mesothelioma relevant scenario can take months or a long time to complete. Don't have double thoughts, right now could be the time to get hold of a attorney following being clinically diagnosed and file injury and compensation statements. All of us realize that possessing cancer has an effect on the way you reside in addition to the household members around you. Start off right away and really don't watch for all those fiscal troubles to arrive. As many of us know the treatment method of mesotholioma is very expensive, along with the suffering that you are acquiring isn't your wrong doing. Wanting to know support from attorneys does not only help save your lifestyle but additionally the struggles of the family members.

Inside the middle 20th century, asbestos fiber has been all over the planet, and regarded because the champion of insulating material. Lots of sectors use asbestos fiber in attics, and a few make use of asbestos in order to wrap exhaust manifolds of bulldozers. The power of asbestos to be warmth resistant and inconsumable by flame created it well-known. Staff of businesses which makes asbestos might have a large chance of acquiring mesotholoima. There are also cases by which that folks residing near an asbestos facility suffered signs and symptoms of asbestosis. This only reveals how harmful the material is. The fibers might be leaves worker's outfits as well as shoes.??

It had been on 1970s whenever issues have been raised regarding the very long expression impact from its publicity. In 1974, manufacturing of asbestos fiber ended up being halted. As we can see there is a large asbestos era with a fantastic chance that your employee continues to be exposed. It can be not simply on asbestos facilities wherein a person can be exposed. I understand some steel businesses that buy mesothelioma textile and applied it on roofs for insulating material. Someone that works on that area is very likely to become exposed by this lifestyle threatening material.??

If asbestos fiber continues to be halted throughout 1970's, then what about these homes and properties which were made in advance of that yr? There exists a possibility that structures manufactured in advance of the early 70s might have asbestos fiber material. Exactly what if this unique property or constructing will undertake a few months of redevelopment? This means that construction workers is going to be uncovered by asbestos. They need to carry with them safety mask in order to avoid inhaling the deadly substance. And construction corporations should supply disposable doing work apparel.

Exactly what mesotholioma lawyers can do is assist you to receive the settlement. They'll support you in filing a circumstance which will soon aid you and your relatives economically. You'll find countless asbestos related cases which have been filed. And it can be widely been told that asbestos manufacturers will supply settlement deal than going difficult within the court room. Be warned that there's also lawyers that may concur for that resolution of the situation made available by asbestos producers. Please do not aim for negotiation of the case. Get a superior lawyer that will be there for you till the finish. You really do not need to be worried about the case because your circumstance as well as your sickness are thought to be to be the very best proof.

Find out how you can locate the very best asbestos attorneys

When you have already been clinically determined to have mesotholioma due to asbestos fiber coverage, after that ask legal aid from mesotholioma lawyers straight away. These kind of attorneys might be there in your case in the filling of your respective situation until finally you may end up being rewarded effectively. The legal course of action for mesothelioma relevant scenario can take months or a long time to complete. Don't have double thoughts, right now could be the time to get hold of a attorney following being clinically diagnosed and file injury and compensation statements. All of us realize that possessing cancer has an effect on the way you reside in addition to the household members around you. Start off right away and really don't watch for all those fiscal troubles to arrive. As many of us know the treatment method of mesotholioma is very expensive, along with the suffering that you are acquiring isn't your wrong doing. Wanting to know support from attorneys does not only help save your lifestyle but additionally the struggles of the family members.

Inside the middle 20th century, asbestos fiber has been all over the planet, and regarded because the champion of insulating material. Lots of sectors use asbestos fiber in attics, and a few make use of asbestos in order to wrap exhaust manifolds of bulldozers. The power of asbestos to be warmth resistant and inconsumable by flame created it well-known. Staff of businesses which makes asbestos might have a large chance of acquiring mesotholoima. There are also cases by which that folks residing near an asbestos facility suffered signs and symptoms of asbestosis. This only reveals how harmful the material is. The fibers might be leaves worker's outfits as well as shoes.??

It had been on 1970s whenever issues have been raised regarding the very long expression impact from its publicity. In 1974, manufacturing of asbestos fiber ended up being halted. As we can see there is a large asbestos era with a fantastic chance that your employee continues to be exposed. It can be not simply on asbestos facilities wherein a person can be exposed. I understand some steel businesses that buy mesothelioma textile and applied it on roofs for insulating material. Someone that works on that area is very likely to become exposed by this lifestyle threatening material.??

If asbestos fiber continues to be halted throughout 1970's, then what about these homes and properties which were made in advance of that yr? There exists a possibility that structures manufactured in advance of the early 70s might have asbestos fiber material. Exactly what if this unique property or constructing will undertake a few months of redevelopment? This means that construction workers is going to be uncovered by asbestos. They need to carry with them safety mask in order to avoid inhaling the deadly substance. And construction corporations should supply disposable doing work apparel.

Exactly what mesotholioma lawyers can do is assist you to receive the settlement. They'll support you in filing a circumstance which will soon aid you and your relatives economically. You'll find countless asbestos related cases which have been filed. And it can be widely been told that asbestos manufacturers will supply settlement deal than going difficult within the court room. Be warned that there's also lawyers that may concur for that resolution of the situation made available by asbestos producers. Please do not aim for negotiation of the case. Get a superior lawyer that will be there for you till the finish. You really do not need to be worried about the case because your circumstance as well as your sickness are thought to be to be the very best proof.

Mesothelioma Injury

Mesothelioma injury incidents are caused by exposure to asbestos. Asbestos was once perceived as one of the greatest building materials in history because of its durability and fire resistance. Unfortunately, there have been a number of life-threatening problems associated with this substance. The use of asbestos was found to be the cause of diseases like Asbestosis and Mesothelioma, which is a cancer of the membranes in the lungs, the abdominal cavity, or the heart and present the following symptoms:

?? abdominal pain or "fullness"
?? chest pain
?? difficulty swallowing
?? fluid in the lining of the lungs
?? lower back pain
?? loss of appetite
?? persistent coughing
?? shortness of breath
?? weakness

Texas is amongst the top ten states that show the highest number in Mesothelioma injury incidents. It is currently ranked number five behind Florida, New York, Pennsylvania and California. The reason why location is so critical with diagnosis is because of the industries in these states that use an abundance of Asbestos, such as shipyards, construction sites using the material, and petroleum companies. Medical studies show that 86% of workers with 20 or more years of shipbuilding experience suffer from an asbestos-related disease.

Mesothelioma Injury

Mesothelioma injury incidents are caused by exposure to asbestos. Asbestos was once perceived as one of the greatest building materials in history because of its durability and fire resistance. Unfortunately, there have been a number of life-threatening problems associated with this substance. The use of asbestos was found to be the cause of diseases like Asbestosis and Mesothelioma, which is a cancer of the membranes in the lungs, the abdominal cavity, or the heart and present the following symptoms:

?? abdominal pain or "fullness"
?? chest pain
?? difficulty swallowing
?? fluid in the lining of the lungs
?? lower back pain
?? loss of appetite
?? persistent coughing
?? shortness of breath
?? weakness

Texas is amongst the top ten states that show the highest number in Mesothelioma injury incidents. It is currently ranked number five behind Florida, New York, Pennsylvania and California. The reason why location is so critical with diagnosis is because of the industries in these states that use an abundance of Asbestos, such as shipyards, construction sites using the material, and petroleum companies. Medical studies show that 86% of workers with 20 or more years of shipbuilding experience suffer from an asbestos-related disease.

How to deal with mesothelioma

Living with cancer is not easy, of course. And the life of a cancer such as mesothelioma is feared much worse. But with the increasing incidence of mesothelioma around the world, many people are fighting for their lives and improve the quality of life. We live life, every moment to the best of us, this is the real thing in the world for patients with mesothelioma.'m Desperate to maintain extra innings and live the life you love so muchmuch. But for many patients, fate has other plans. The prognosis for this cancer is rather poor for most patients diagnosed late with him are due to similar symptoms to other diseases such as pneumonia. But hope is certainly more in these days with new treatment options.

- Asbestos lung mesothelioma

apt hospital equipment and treatment, mesothelioma cancer patients improve their quality of life these days, but they need to improve, as on many fronts of lifefollows:

How to deal with mesothelioma

Living with cancer is not easy, of course. And the life of a cancer such as mesothelioma is feared much worse. But with the increasing incidence of mesothelioma around the world, many people are fighting for their lives and improve the quality of life. We live life, every moment to the best of us, this is the real thing in the world for patients with mesothelioma.'m Desperate to maintain extra innings and live the life you love so muchmuch. But for many patients, fate has other plans. The prognosis for this cancer is rather poor for most patients diagnosed late with him are due to similar symptoms to other diseases such as pneumonia. But hope is certainly more in these days with new treatment options.

- Asbestos lung mesothelioma

apt hospital equipment and treatment, mesothelioma cancer patients improve their quality of life these days, but they need to improve, as on many fronts of lifefollows:

Inflammatory Disorders and the Increased Occurrence of Mesothelioma

A better understanding of asbestos related diseases is necessary if we are ever to find a cure to Mesothelioma.?? One interesting study is called, "Immunohistochemical localization of transforming growth factor beta isoforms in asbestos-related diseases." By J Jagirdar, T C Lee, J Reibman, L I Gold, C Aston, R Bégin, and W N Rom - Environ Health Perspect. 1997 September; 105(Suppl 5): 1197–1203.?? Here is an excerpt: "Abstract - Transforming growth factor beta (TGF-beta), a multifunctional cytokine and growth factor, plays a key role in scarring and fibrotic processes because of its ability to induce extracellular matrix proteins and modulate the growth and immune function of many cell types. These effects are important in inflammatory disorders with fibrosis and cancer. The asbestos-related diseases are characterized by fibrosis in the lower respiratory tract and pleura and increased occurrence of lung cancer and mesothelioma. We performed immunohistochemistry with isoform-specific antibodies to the three TGF-beta isoforms on 16 autopsy lungs from Quebec, Canada, asbestos miners and millers. There was increased immunolocalization of all three TGF-beta isoforms in the fibrotic lesions of asbestosis and pleural fibrosis. The hyperplastic type II pneumocytes contained all three isoforms. By contrast, there was differential spatial immunostaining for the TGF-beta isoforms in malignant mesothelioma, with TGF-beta 1 in the stroma but TGF-beta 2 in the tumor cells. These data are consistent with an important role for TGF-beta in accumulation of extracellular matrix and cell proliferation in asbestos-related diseases."

A second study is called, "Asbestos and Benzo(a)pyrene Synergism in the Transformation of Syrian Hamster Embryo Cells" by Joseph A. DiPaolo, Anthony J. DeMarinis, Jay Doniger - Pharmacology 1983;27:65-73.?? Here is an excerpt: "Abstract - Four varieties of asbestos fibers, crocidolite, anthophyllite, amosite, and chrysotile, induced a low rate of morphologic transformation in Syrian hamster cells. Of the four tested, chrysotile was the most lethal as reflected by colony survival. When cells were exposed to 1 μg of benzo(a)pyrene (BP)&slash;l ml medium or 3 J/m2 ultraviolet irradiation and to different concentrations of the asbestos fibers, an enhancement of transformation occurred only with BP. The enhancement was dose responsive with all fiber species except for amosite which was dose independent. The synergistic activity of BP and asbestos suggests that asbestos facilitates the transport of BP to the cell site(s) critical for transformation. These results provide a basis for investigating the carcinogenic and cocarcinogenic potential of asbestos fibers in mammalian cells."

Another interesting study is called, "Interaction of asbestos with alveolar cells" by Yasunosuke Suzuki - Environ Health Perspect. 1974 December; 9: 241–252.?? Here is an excerpt: "Abstract - A number of electron microphotographs are presented showing the various aspects of phagocytosis of fibers in lung tissue.?? The fibers were rapidly phagocytosed by alveolar macrophages, by polymorphonuclear leucocytes, and less frequently by alveolar epithelial cells. They were also found in the cytoplasm of the alveolar stromal macrophages. In the late stage of the disease, macrophages containing the minerals were recognized in the fibrous submesothelial connective tissues. In this stage, a cell intermediate in structure between the epithelial cell and the macrophage was observed in the alveolar lining. This cell showed strong phagocytic activity against the fibers.The process of phagocytosis of the fibers was quite similar to that of other microparticles such as Thorotrast and India ink. It had been suggested that phagosomes containing the fibers became transformed into secondary lysosomes.The fate of the phagocytosed fibers varied. Some were partly dissolved or digested with marked reduction in the thickness of the wall of the chrysotile fibril. Many became coated by hemosiderin which accumulated in the cytoplasm of the phagocytic cells. This coating transformed the fibers into asbestos bodies. Finally many fibers were released because of the death of the host cell. Uncoated fibers as well as various stages of phagocytosis were observed in all animals, including those 1 to 2 years after the instillation of asbestos. This strongly suggests that fibers may be repeatedly phagocytosed, released and ephagocytosed, inducing a continuous response of the alveolar cells and maintaining the disease."

We all owe a debt of gratitude to these fine researchers for their hard work and dedication.?? If you found any of these excerpts interesting, please read the studies in their entirety.

Inflammatory Disorders and the Increased Occurrence of Mesothelioma

A better understanding of asbestos related diseases is necessary if we are ever to find a cure to Mesothelioma.?? One interesting study is called, "Immunohistochemical localization of transforming growth factor beta isoforms in asbestos-related diseases." By J Jagirdar, T C Lee, J Reibman, L I Gold, C Aston, R Bégin, and W N Rom - Environ Health Perspect. 1997 September; 105(Suppl 5): 1197–1203.?? Here is an excerpt: "Abstract - Transforming growth factor beta (TGF-beta), a multifunctional cytokine and growth factor, plays a key role in scarring and fibrotic processes because of its ability to induce extracellular matrix proteins and modulate the growth and immune function of many cell types. These effects are important in inflammatory disorders with fibrosis and cancer. The asbestos-related diseases are characterized by fibrosis in the lower respiratory tract and pleura and increased occurrence of lung cancer and mesothelioma. We performed immunohistochemistry with isoform-specific antibodies to the three TGF-beta isoforms on 16 autopsy lungs from Quebec, Canada, asbestos miners and millers. There was increased immunolocalization of all three TGF-beta isoforms in the fibrotic lesions of asbestosis and pleural fibrosis. The hyperplastic type II pneumocytes contained all three isoforms. By contrast, there was differential spatial immunostaining for the TGF-beta isoforms in malignant mesothelioma, with TGF-beta 1 in the stroma but TGF-beta 2 in the tumor cells. These data are consistent with an important role for TGF-beta in accumulation of extracellular matrix and cell proliferation in asbestos-related diseases."

A second study is called, "Asbestos and Benzo(a)pyrene Synergism in the Transformation of Syrian Hamster Embryo Cells" by Joseph A. DiPaolo, Anthony J. DeMarinis, Jay Doniger - Pharmacology 1983;27:65-73.?? Here is an excerpt: "Abstract - Four varieties of asbestos fibers, crocidolite, anthophyllite, amosite, and chrysotile, induced a low rate of morphologic transformation in Syrian hamster cells. Of the four tested, chrysotile was the most lethal as reflected by colony survival. When cells were exposed to 1 μg of benzo(a)pyrene (BP)&slash;l ml medium or 3 J/m2 ultraviolet irradiation and to different concentrations of the asbestos fibers, an enhancement of transformation occurred only with BP. The enhancement was dose responsive with all fiber species except for amosite which was dose independent. The synergistic activity of BP and asbestos suggests that asbestos facilitates the transport of BP to the cell site(s) critical for transformation. These results provide a basis for investigating the carcinogenic and cocarcinogenic potential of asbestos fibers in mammalian cells."

Another interesting study is called, "Interaction of asbestos with alveolar cells" by Yasunosuke Suzuki - Environ Health Perspect. 1974 December; 9: 241–252.?? Here is an excerpt: "Abstract - A number of electron microphotographs are presented showing the various aspects of phagocytosis of fibers in lung tissue.?? The fibers were rapidly phagocytosed by alveolar macrophages, by polymorphonuclear leucocytes, and less frequently by alveolar epithelial cells. They were also found in the cytoplasm of the alveolar stromal macrophages. In the late stage of the disease, macrophages containing the minerals were recognized in the fibrous submesothelial connective tissues. In this stage, a cell intermediate in structure between the epithelial cell and the macrophage was observed in the alveolar lining. This cell showed strong phagocytic activity against the fibers.The process of phagocytosis of the fibers was quite similar to that of other microparticles such as Thorotrast and India ink. It had been suggested that phagosomes containing the fibers became transformed into secondary lysosomes.The fate of the phagocytosed fibers varied. Some were partly dissolved or digested with marked reduction in the thickness of the wall of the chrysotile fibril. Many became coated by hemosiderin which accumulated in the cytoplasm of the phagocytic cells. This coating transformed the fibers into asbestos bodies. Finally many fibers were released because of the death of the host cell. Uncoated fibers as well as various stages of phagocytosis were observed in all animals, including those 1 to 2 years after the instillation of asbestos. This strongly suggests that fibers may be repeatedly phagocytosed, released and ephagocytosed, inducing a continuous response of the alveolar cells and maintaining the disease."

We all owe a debt of gratitude to these fine researchers for their hard work and dedication.?? If you found any of these excerpts interesting, please read the studies in their entirety.

Inflammatory Disorders and the Increased Occurrence of Mesothelioma

A better understanding of asbestos related diseases is necessary if we are ever to find a cure to Mesothelioma.?? One interesting study is called, "Immunohistochemical localization of transforming growth factor beta isoforms in asbestos-related diseases." By J Jagirdar, T C Lee, J Reibman, L I Gold, C Aston, R Bégin, and W N Rom - Environ Health Perspect. 1997 September; 105(Suppl 5): 1197–1203.?? Here is an excerpt: "Abstract - Transforming growth factor beta (TGF-beta), a multifunctional cytokine and growth factor, plays a key role in scarring and fibrotic processes because of its ability to induce extracellular matrix proteins and modulate the growth and immune function of many cell types. These effects are important in inflammatory disorders with fibrosis and cancer. The asbestos-related diseases are characterized by fibrosis in the lower respiratory tract and pleura and increased occurrence of lung cancer and mesothelioma. We performed immunohistochemistry with isoform-specific antibodies to the three TGF-beta isoforms on 16 autopsy lungs from Quebec, Canada, asbestos miners and millers. There was increased immunolocalization of all three TGF-beta isoforms in the fibrotic lesions of asbestosis and pleural fibrosis. The hyperplastic type II pneumocytes contained all three isoforms. By contrast, there was differential spatial immunostaining for the TGF-beta isoforms in malignant mesothelioma, with TGF-beta 1 in the stroma but TGF-beta 2 in the tumor cells. These data are consistent with an important role for TGF-beta in accumulation of extracellular matrix and cell proliferation in asbestos-related diseases."

A second study is called, "Asbestos and Benzo(a)pyrene Synergism in the Transformation of Syrian Hamster Embryo Cells" by Joseph A. DiPaolo, Anthony J. DeMarinis, Jay Doniger - Pharmacology 1983;27:65-73.?? Here is an excerpt: "Abstract - Four varieties of asbestos fibers, crocidolite, anthophyllite, amosite, and chrysotile, induced a low rate of morphologic transformation in Syrian hamster cells. Of the four tested, chrysotile was the most lethal as reflected by colony survival. When cells were exposed to 1 μg of benzo(a)pyrene (BP)&slash;l ml medium or 3 J/m2 ultraviolet irradiation and to different concentrations of the asbestos fibers, an enhancement of transformation occurred only with BP. The enhancement was dose responsive with all fiber species except for amosite which was dose independent. The synergistic activity of BP and asbestos suggests that asbestos facilitates the transport of BP to the cell site(s) critical for transformation. These results provide a basis for investigating the carcinogenic and cocarcinogenic potential of asbestos fibers in mammalian cells."

Another interesting study is called, "Interaction of asbestos with alveolar cells" by Yasunosuke Suzuki - Environ Health Perspect. 1974 December; 9: 241–252.?? Here is an excerpt: "Abstract - A number of electron microphotographs are presented showing the various aspects of phagocytosis of fibers in lung tissue.?? The fibers were rapidly phagocytosed by alveolar macrophages, by polymorphonuclear leucocytes, and less frequently by alveolar epithelial cells. They were also found in the cytoplasm of the alveolar stromal macrophages. In the late stage of the disease, macrophages containing the minerals were recognized in the fibrous submesothelial connective tissues. In this stage, a cell intermediate in structure between the epithelial cell and the macrophage was observed in the alveolar lining. This cell showed strong phagocytic activity against the fibers.The process of phagocytosis of the fibers was quite similar to that of other microparticles such as Thorotrast and India ink. It had been suggested that phagosomes containing the fibers became transformed into secondary lysosomes.The fate of the phagocytosed fibers varied. Some were partly dissolved or digested with marked reduction in the thickness of the wall of the chrysotile fibril. Many became coated by hemosiderin which accumulated in the cytoplasm of the phagocytic cells. This coating transformed the fibers into asbestos bodies. Finally many fibers were released because of the death of the host cell. Uncoated fibers as well as various stages of phagocytosis were observed in all animals, including those 1 to 2 years after the instillation of asbestos. This strongly suggests that fibers may be repeatedly phagocytosed, released and ephagocytosed, inducing a continuous response of the alveolar cells and maintaining the disease."

We all owe a debt of gratitude to these fine researchers for their hard work and dedication.?? If you found any of these excerpts interesting, please read the studies in their entirety.

Mesothelioma Facts to Know

Mesothelioma Facts: This disease sadly takes people who are infected by surprise as the symptoms usually occur many years after exposure to asbestos. In general, exposure to asbestos which leads to the mesothelioma illness happens in the workplace. The infected mesothelium cells become cancerous and possibly without the knowledge of the victim, the infectious cells begin spreading into the different regions of the victim's body.

Due to the nature of work in workplaces with asbestos in the past, such as manufacturing plants or power plants, most patients are men, although women are also sometimes victims also. In the U.S. only, there are around 200 new cases per month. Also to note, these are only known instances. It is unclear how many people at this time who are ill with mesothelioma, but not realize the magnitude of their condition.

Mesothelioma Facts to Know

Mesothelioma Facts: This disease sadly takes people who are infected by surprise as the symptoms usually occur many years after exposure to asbestos. In general, exposure to asbestos which leads to the mesothelioma illness happens in the workplace. The infected mesothelium cells become cancerous and possibly without the knowledge of the victim, the infectious cells begin spreading into the different regions of the victim's body.

Due to the nature of work in workplaces with asbestos in the past, such as manufacturing plants or power plants, most patients are men, although women are also sometimes victims also. In the U.S. only, there are around 200 new cases per month. Also to note, these are only known instances. It is unclear how many people at this time who are ill with mesothelioma, but not realize the magnitude of their condition.

Spanish firm to fork out hundreds of thousands in asbestos lawsuit

SPAIN - A Spanish production company was purchased to spend above three million Euros in an asbestos lawsuit.

Uralita, a creating material provider, was court purchased to pay out the sum to 45 persons who have been exposed to asbestos from the company's cement factory and have incurred subsequent wellness difficulties.

The use of asbestos in construction and manufacturing was banned in the country in 2001. Even so, the provider had been utilizing asbestos in their cement production for decades.

The victims lived close to the factory and incurred injury to their lungs. Some are suffering from mesothelioma.

This is the first time that a Spanish court has purchased a organization to compensate persons for overall health problems similar to asbestos publicity.

Subjection to asbestos can result in a number of healthiness troubles, including mesothelioma. A uncommon cancer, mesothelioma is very challenging to diagnose and deal with. It normally goes unnoticed for many years simply because signs and symptoms can take decades to manifest.

Spanish firm to fork out hundreds of thousands in asbestos lawsuit

SPAIN - A Spanish production company was purchased to spend above three million Euros in an asbestos lawsuit.

Uralita, a creating material provider, was court purchased to pay out the sum to 45 persons who have been exposed to asbestos from the company's cement factory and have incurred subsequent wellness difficulties.

The use of asbestos in construction and manufacturing was banned in the country in 2001. Even so, the provider had been utilizing asbestos in their cement production for decades.

The victims lived close to the factory and incurred injury to their lungs. Some are suffering from mesothelioma.

This is the first time that a Spanish court has purchased a organization to compensate persons for overall health problems similar to asbestos publicity.

Subjection to asbestos can result in a number of healthiness troubles, including mesothelioma. A uncommon cancer, mesothelioma is very challenging to diagnose and deal with. It normally goes unnoticed for many years simply because signs and symptoms can take decades to manifest.

Mesothelioma and Small Cell or Pleomorphic Patterns

Another interesting study is called, "Malignant epithelioid mesothelioma: anti-mesothelial marker expression correlates with histological pattern" by R L Attanoos, R Webb, S D Dojcinov, A R Gibbs – Histopathology Volume 39, Issue 6, pages 584–588, December 2001.?? Here is an excerpt: "Malignant epithelioid mesothelioma: anti-mesothelial marker expression correlates with histological pattern - Aims:??Malignant epithelioid mesothelioma shows marked cytoarchitectural diversity. The aim of the study was to evaluate how immunoreactivity with mesothelial markers related to histological pattern.

Methods and results:Ninety-two cases of malignant epithelioid mesothelioma (60 pleural, 32 peritoneal) were examined and classified as exhibiting tubulopapillary, adenomatoid, solid, small cell or pleomorphic patterns. All cases were immunohistochemically stained with thrombomodulin, calretinin, CD44H, and cytokeratin 5/6. Cases of malignant mesothelioma exhibited a number of different histological forms. Immunohistochemical expression of each mesothelial marker tested was not homogeneous across different histological patterns of malignant epithelioid mesothelioma, even within the same tumour section. Calretinin (with nuclear expression) was identified to show the highest overall sensitivity and lowest range variation in staining (67% sensitivity in small cell areas to 100% expression in pleomorphic areas). Cytokeratin 5/6 and thrombomodulin yielded similar overall sensitivity. Thrombomodulin appeared to demonstrate higher sensitivity for small cell variant tumour (83% sensitivity). A notable advantage with cytokeratin 5/6 was that expression was more diffuse in nature rather than the focal membranous elaboration seen in thrombomodulin. The widest range of staining was seen in small cell mesothelioma (83% sensitivity with thrombomodulin to 17% sensitivity with cytokeratin 5/6) and in tubulopapillary areas (90% sensitivity with calretinin to 38% sensitivity with CD44H).

Conclusions:Calretinin appears most useful and shows the highest overall sensitivity for malignant epithelioid mesothelioma, with good expression in areas displaying a tubulopapillary, adenomatoid, solid and pleomorphic pattern. For small cell mesothelioma, thrombomodulin appears to confer higher sensitivity and is advocated, in this setting, as the first line mesothelial marker. Cytokeratin 5/6 is a useful and easily interpretable mesothelial marker. CD44H is not of particular use in the diagnosis of malignant epithelioid mesothelioma. Accurate interpretation of immunohistochemistry in mesothelioma requires an awareness of the immunophenotypic heterogeneity identified in different histological forms of the tumour, and this is of particular importance in small biopsies."

Another interesting study is called, "Serologic responses in patients with malignant mesothelioma: evidence for both public and private specificities." By Robinson C, Callow M, Stevenson S, Scott B, Robinson BW, Lake RA - Am J Respir Cell Mol Biol. 2000 May;22(5):550-6. - University Department of Medicine, Western Australian Institute for Medical Research, Queen Elizabeth II Medical Centre, Perth, Western Australia, Australia.?? Here is an excerpt: "Malignant mesothelioma (MM) is a pulmonary malignancy that appears to be immunogenic based on a large number of studies in both animals and humans. This notion is supported by our recent demonstration using Western blot analysis of immunoglobulin G antibodies reactive with a variety of autoantigens in many patients with MM. In view of the enormous potential of such antigens in early diagnosis, immunotherapy, and vaccination of at-risk individuals, it was essential to identify these antigens. We therefore applied the SEREX technique (serologic identification by recombinant expression cloning), using a serum pool from six patients as the probe against an expressed complementary DNA library derived from a cloned MM cell line. We screened over one million recombinants and obtained sequence information on eight antigens that had provoked immunoglobulin heavy chain class switching, presumably as a consequence of T-cell recognition. Six of these antigens were identifiable (U2AF[65], Siah binding protein, topoisomerase IIbeta, ZFM1, mIre1, and pendulin), and of the others, one was found as a single EST from a myotube library (Jemm-1); the other (Jemm-2) was not represented in any EST database even as a weak homolog. Consistent with our previous findings, each of the characterizable antigens would be expected to be associated with the cell nucleus. Each of the autoantibody specificities was uniquely associated with a single patient with the exception of antibodies to TOPIIbeta and U2AF(65). We found 13 of 14 (93%) patients with MM had antibodies to TOPIIbeta and two of 14 (14%) patients had antibodies to U2AF(65). The number of serum reactivities, taken as a measure of the complexity of the immune response, correlates with patient survival and with an index of systemic inflammation. These data suggest that a broader range of serologic reactivities reflects a more active host response to the presence of tumor."

We all owe a debt of gratitude to these fine researchers.?? If you found any of these excerpts interesting, please read the studies in their entirety.

Mesothelioma and Small Cell or Pleomorphic Patterns

Another interesting study is called, "Malignant epithelioid mesothelioma: anti-mesothelial marker expression correlates with histological pattern" by R L Attanoos, R Webb, S D Dojcinov, A R Gibbs – Histopathology Volume 39, Issue 6, pages 584–588, December 2001.?? Here is an excerpt: "Malignant epithelioid mesothelioma: anti-mesothelial marker expression correlates with histological pattern - Aims:??Malignant epithelioid mesothelioma shows marked cytoarchitectural diversity. The aim of the study was to evaluate how immunoreactivity with mesothelial markers related to histological pattern.

Methods and results:Ninety-two cases of malignant epithelioid mesothelioma (60 pleural, 32 peritoneal) were examined and classified as exhibiting tubulopapillary, adenomatoid, solid, small cell or pleomorphic patterns. All cases were immunohistochemically stained with thrombomodulin, calretinin, CD44H, and cytokeratin 5/6. Cases of malignant mesothelioma exhibited a number of different histological forms. Immunohistochemical expression of each mesothelial marker tested was not homogeneous across different histological patterns of malignant epithelioid mesothelioma, even within the same tumour section. Calretinin (with nuclear expression) was identified to show the highest overall sensitivity and lowest range variation in staining (67% sensitivity in small cell areas to 100% expression in pleomorphic areas). Cytokeratin 5/6 and thrombomodulin yielded similar overall sensitivity. Thrombomodulin appeared to demonstrate higher sensitivity for small cell variant tumour (83% sensitivity). A notable advantage with cytokeratin 5/6 was that expression was more diffuse in nature rather than the focal membranous elaboration seen in thrombomodulin. The widest range of staining was seen in small cell mesothelioma (83% sensitivity with thrombomodulin to 17% sensitivity with cytokeratin 5/6) and in tubulopapillary areas (90% sensitivity with calretinin to 38% sensitivity with CD44H).

Conclusions:Calretinin appears most useful and shows the highest overall sensitivity for malignant epithelioid mesothelioma, with good expression in areas displaying a tubulopapillary, adenomatoid, solid and pleomorphic pattern. For small cell mesothelioma, thrombomodulin appears to confer higher sensitivity and is advocated, in this setting, as the first line mesothelial marker. Cytokeratin 5/6 is a useful and easily interpretable mesothelial marker. CD44H is not of particular use in the diagnosis of malignant epithelioid mesothelioma. Accurate interpretation of immunohistochemistry in mesothelioma requires an awareness of the immunophenotypic heterogeneity identified in different histological forms of the tumour, and this is of particular importance in small biopsies."

Another interesting study is called, "Serologic responses in patients with malignant mesothelioma: evidence for both public and private specificities." By Robinson C, Callow M, Stevenson S, Scott B, Robinson BW, Lake RA - Am J Respir Cell Mol Biol. 2000 May;22(5):550-6. - University Department of Medicine, Western Australian Institute for Medical Research, Queen Elizabeth II Medical Centre, Perth, Western Australia, Australia.?? Here is an excerpt: "Malignant mesothelioma (MM) is a pulmonary malignancy that appears to be immunogenic based on a large number of studies in both animals and humans. This notion is supported by our recent demonstration using Western blot analysis of immunoglobulin G antibodies reactive with a variety of autoantigens in many patients with MM. In view of the enormous potential of such antigens in early diagnosis, immunotherapy, and vaccination of at-risk individuals, it was essential to identify these antigens. We therefore applied the SEREX technique (serologic identification by recombinant expression cloning), using a serum pool from six patients as the probe against an expressed complementary DNA library derived from a cloned MM cell line. We screened over one million recombinants and obtained sequence information on eight antigens that had provoked immunoglobulin heavy chain class switching, presumably as a consequence of T-cell recognition. Six of these antigens were identifiable (U2AF[65], Siah binding protein, topoisomerase IIbeta, ZFM1, mIre1, and pendulin), and of the others, one was found as a single EST from a myotube library (Jemm-1); the other (Jemm-2) was not represented in any EST database even as a weak homolog. Consistent with our previous findings, each of the characterizable antigens would be expected to be associated with the cell nucleus. Each of the autoantibody specificities was uniquely associated with a single patient with the exception of antibodies to TOPIIbeta and U2AF(65). We found 13 of 14 (93%) patients with MM had antibodies to TOPIIbeta and two of 14 (14%) patients had antibodies to U2AF(65). The number of serum reactivities, taken as a measure of the complexity of the immune response, correlates with patient survival and with an index of systemic inflammation. These data suggest that a broader range of serologic reactivities reflects a more active host response to the presence of tumor."

We all owe a debt of gratitude to these fine researchers.?? If you found any of these excerpts interesting, please read the studies in their entirety.

11.17.2011

Peritoneal Mesothelioma Cancer Facts

Malignant peritoneal mesothelioma is a rare form of mesothelioma that attack the lining of abdomen peritoneum. Malignant peritoneal mesothelioma (MPM) is regarded as a universally fatal disease affecting 20% to 30% of mesothelioma cases. It's was first described by Miller and Wynn in year 1908. In the past two decades, the incidence of malignant peritoneal mesothelioma has increased.

Peritoneal mesothelioma affects the lining of the abdomen known as the peritoneum. Because of the location of malignant cell is human's abdominal lining, peritoneal mesothelioma can sometimes known as abdominal mesothelioma.

The exactly known cause of the malignant pleaural mesothelioma in human is asbestos. Asbestos exposure contributed to almost 70 to 80 percent of mesothelioma lung cancer. Humans come into contact with asbestos when they swallow or inhale the fibers may increased risk to develop asbestos related disease most importantly mesothelioma.

Asbestos was completely banned in UK because it was recognized to be a serious health hazard, and it is now responsible for about 4000 deaths each year and many cases of serious disease. The people at increase risk of developing health asbestos related are those whose work brings them into direct contact with asbestos such as builders, heating engineers, roofers and demolition workers. If you find yourself to fall in this group, better to take some precautions.

Peritoneal Mesothelioma Cancer Facts

Malignant peritoneal mesothelioma is a rare form of mesothelioma that attack the lining of abdomen peritoneum. Malignant peritoneal mesothelioma (MPM) is regarded as a universally fatal disease affecting 20% to 30% of mesothelioma cases. It's was first described by Miller and Wynn in year 1908. In the past two decades, the incidence of malignant peritoneal mesothelioma has increased.

Peritoneal mesothelioma affects the lining of the abdomen known as the peritoneum. Because of the location of malignant cell is human's abdominal lining, peritoneal mesothelioma can sometimes known as abdominal mesothelioma.

The exactly known cause of the malignant pleaural mesothelioma in human is asbestos. Asbestos exposure contributed to almost 70 to 80 percent of mesothelioma lung cancer. Humans come into contact with asbestos when they swallow or inhale the fibers may increased risk to develop asbestos related disease most importantly mesothelioma.

Asbestos was completely banned in UK because it was recognized to be a serious health hazard, and it is now responsible for about 4000 deaths each year and many cases of serious disease. The people at increase risk of developing health asbestos related are those whose work brings them into direct contact with asbestos such as builders, heating engineers, roofers and demolition workers. If you find yourself to fall in this group, better to take some precautions.

Mesothelioma Histologic Findings and Platelet Counts

Another interesting study is called, "The role of extrapleural pneumonectomy in malignant pleural mesothelioma. A Lung Cancer Study Group trial" by VW Rusch, S Piantadosi and EC Holmes - Memorial Sloan-Kettering Cancer Center, New York, N.Y. The Journal of Thoracic and Cardiovascular Surgery, Vol 102, 1-9 – Here is an excerpt: "Malignant pleural mesothelioma is usually a fatal cancer for which operation has been the mainstay of treatment because chemotherapy and radiation are relatively ineffective. The choice of operation for malignant pleural mesothelioma remains controversial. Extrapleural pneumonectomy has been advocated because it allows complete removal of gross tumor and can be associated with long-term survival. To evaluate extrapleural pneumonectomy, we conducted a prospective multiinstitutional trial in patients with biopsy-proved previously untreated malignant pleural mesothelioma. Criteria for extrapleural pneumonectomy were (1) potentially completely resectable unilateral disease by computed tomography scan, (2) predicted postresection forced expiratory volume in 1 second greater than 1 L/sec, and (3) no other major medical problems. Patients who were not candidates for extrapleural pneumonectomy had a more limited operation with or without adjuvant therapy or had nonsurgical treatment. From September 1985 to June 1988 83 eligible patients (64 male, 19 female) were entered. The mean age for all patients was 59.7 years. Only 20 of the 83 patients (24%) underwent extrapleural pneumonectomy. Three of these 20 patients (15%) died postoperatively. The recurrence-free survival was significantly longer for the patients undergoing extrapleural pneumonectomy than for the other two groups (p = 0.03), but there was no difference in overall survival among the three groups. In univariate analyses, epithelial versus sarcomatoid and mixed histologic findings and platelet count less than 400,000 were associated with a better overall survival (p = 0.02), and performance status (Karnofsky less than 80) was predictive of recurrence (p = 0.02). In a multivariate analysis, histologic findings, sex, age, extrapleural pneumonectomy, weight loss, and performance status all had no significant impact on survival. Extrapleural pneumonectomy was associated with a greater likelihood of relapse in distant sites than were limited operation and nonsurgical treatment. We conclude that (1) only a small proportion of all patients with malignant pleural mesothelioma are candidates for extrapleural pneumonectomy, (2) extrapleural pneumonectomy carries a significant operative mortality and does not seem to improve overall survival compared with more conservative forms of treatment, (3) extrapleural pneumonectomy alters the patterns of relapse, and (4) factors previously thought to have an impact on survival in other series did not affect outcome in this trial."

Another interesting study is called, "A phase II trial of surgical resection and adjuvant high-dose hemithoracic radiation for malignant pleural Mesothelioma" by Valerie W. Rusch, MD, Kenneth Rosenzweig, MD, Ennapadam Venkatraman, PhD, Larry Leon, MS, Adam Raben, MD, Louis Harrison, MD, Manjit S. Bains, MD, Robert J. Downey, MD, Robert J. Ginsberg, MD - J Thorac Cardiovasc Surg 2001;122:788-795 From the Thoracic Service, Department of Surgery,a the Department of Radiation Oncology,b and the Biostatistics Service, Department of Epidemiology and Biostatistics,c Memorial Sloan-Kettering Cancer Center, New York, NY.?? Here is an excerpt: "Background: Surgical resection of malignant pleural mesothelioma is reported to have up to an 80% rate of local recurrence. We performed a phase II trial of high-dose hemithoracic radiation after complete resection to determine feasibility and to estimate rates of local recurrence and survival.?? Methods: Patients were eligible if they had a resectable tumor, as determined by computed tomographic scanning, and adequate cardiopulmonary function for extrapleural pneumonectomy or pleurectomy/decortication. After complete resection, patients received hemithoracic radiation (54 Gy) and then were followed up with serial computed tomographic scanning.?? Results: From 1995 to 1998, 88 patients (73 men and 15 women; median age, 62.5 years) were entered into the study. The operations performed included 62 extrapleural pneumonectomies (70%) and 5 leurectomies/decortications; procedures for exploration only were performed in 21 patients. Seven (7.9%) patients died postoperatively. Adjuvant radiation administered to 57 patients (54 undergoing extrapleural pneumonectomy and 3 undergoing pleurectomy/decortication) at a median dose of 54 Gy was well tolerated (grade 0-2 fatigue, esophagitis), except for one late esophageal fistula. The median survival was 33.8 months for stage I and II tumors but only 10 months for stage III and IV tumors (P = .04). For the patients undergoing extrapleural pneumonectomy, the sites of recurrence were locoregional in 2, locoregional and distant in 5, and distant only in 30.?? Conclusion: Hemithoracic radiation after complete surgical resection at a dose not previously reported is feasible. This approach dramatically reduces local recurrence and is associated with prolonged survival for early-stage tumors. Stage III disease has a high risk of early distant relapse and should be considered for trials of systemic therapy added to this regimen of resection and radiation."

We all owe a debt of gratitude to these fine researchers.?? If you found any of these excerpts interesting, please read the studies in their entirety.